Ricerc@Sapienza

A growing number of evidences report that aging represents the major risk factor for the development of cardio and cerebrovascular diseases. Understanding Aging from a genetic, biochemical and physiological point of view could be helpful to design a better medical approach and to elaborate the best therapeutic strategy to adopt, without neglecting all the risk factors associated with advanced age. Of course, the better way should always be understanding risk-to-benefit ratio, maintenance of independence and reduction of symptoms.

Migraine is a prevalent primary headache disorder and is usually considered as benign. However, structural and functional changes in the brain of individuals with migraine have been reported. High frequency of white matter abnormalities, silent infarct-like lesions, and volumetric changes in both gray and white matter in individuals with migraine compared to controls have been demonstrated. Functional magnetic resonance imaging (MRI) studies found altered connectivity in both the interictal and ictal phase of migraine.

The many fundamental roto-vibrational resonances of chemical compounds result in strong absorption lines in the mid-infrared region (λ ∼ 2–20 μm). For this reason, mid-infrared spectroscopy plays a key role in label-free sensing, in particular, for chemical recognition, but often lacks the required sensitivity to probe small numbers of molecules. In this work, we propose a vibrational sensing scheme based on Bloch surface waves (BSWs) on 1D photonic crystals to increase the sensitivity of mid-infrared sensors. We report on the design and deposition of CaF2/ZnS 1D photonic crystals.

Featured Application This review will offer a global overview of the chemometric approaches most commonly used in the field of spectroscopy-based food analysis and authentication. Three different scenarios will be surveyed: data exploration, calibration and classification. Basic and simple descriptions of the main multivariate techniques exploited in such a domain along with a comprehensive outline of their most recent and interesting applications will be provided.

In this review, we summarize the most recent advances in monitoring changes induced in fish and other seafood, and meat and meat products, following the application of traditional processing processes by means of conventional and emerging advanced techniques. Selected examples from the literature covering relevant applications of spectroscopic methods (i.e., visible and near infrared (VIS/NIR), mid-infrared (MIR), Raman, nuclear magnetic resonance (NMR), and fluorescence) will be used to illustrate the topics covered in this review.

OBJECTIVES: The role of functional techniques, such as magnetic resonance spectroscopy (H-MRS), as noninvasive tools to increase breast MR imaging reliability has been widely investigated during the last 2 decades. Considering the growing interest in tumor biology and its influence on functional parameters, the aim of this study was to investigate the relationship between H-MRS parameters and breast cancer biomarkers and to evaluate whether the results of H-MRS at 3 T can correlate with established breast cancer prognostic factors in our clinical experience.

Human Dental Pulp Stem Cells (hDPSCs) represent a type of adult mesenchymal stem cells that have the ability to differentiate in vitro in several lineages such as odontoblasts, osteoblasts, chondrocytes, adipocytes and neurons. In the current work, we used hDPSCs as the experimental model to study the role of recombinant prion protein 23–231 (recPrP C ) in the neuronal differentiation process, and in the signal pathway activation of ERK 1/2 and Akt.

A time-dependent analysis of the B0s→ϕγ decay rate is performed to determine the CP -violating observables Sϕγ and Cϕγ and the mixing-induced observable AΔϕγ. The measurement is based on a sample of pp collision data recorded with the LHCb detector, corresponding to an integrated luminosity of 3  fb−1 at center-of-mass energies of 7 and 8 TeV. The measured values are Sϕγ=0.4±0.30±0.11, Cϕγ=0.11±0.29±0.11, and AΔϕγ=−0.67+0.37−0.41±0.17, where the first uncertainty is statistical and the second systematic. This is the first measurement of the observables S and C in radiative B0s decays.

A new baryon state is observed in the Λ0b+− mass spectrum with high significance using a data sample of pp collisions, collected with the LHCb detector at centre-of-mass energies √ = 7, 8 and 13 TeV, corresponding to an integrated luminosity of 9 fb−1. The mass and natural width of the new state are measured to be

A measurement of the branching fraction of the decay B0s→K0SK0S is performed using proton–proton collision data corresponding to an integrated luminosity of 5  fb−1 collected by the LHCb experiment between 2011 and 2016. The branching fraction is determined to be B(B0s→K0SK0S)=[8.3±1.6(stat)±0.9(syst)±0.8(norm)±0.3(fs/fd)]×10−6, where the first uncertainty is statistical, the second is systematic, and the third and fourth are due to uncertainties on the branching fraction of the normalization mode B0→ϕK0S and the ratio of hadronization fractions fs/fd.