Ricerc@Sapienza

Differently from other digestive malignancies, gastric cancer (GC) pathobiology is still little known and understood. Recently, cytopathology and molecular biology on gastric juice/gastric lavage (GJ/GL) of GC patients have provided novel and interesting results in terms of screening, diagnosis, prognosis, and therapy. However, entertaining cytologic examination and molecular test as a unified solo-run test is previously unreported. Our aim was to assess the new parameter "GL Ca 72.4" for GC patients.

Aim: This study focuses on the stomach as an unusual but not rare site of metastasis of breast cancer.
Methods: We performed a literature search on gastric metastasis from breast cancer searching for reviews from
2000 to 2018 and case reports from 2013 to 2018. We found 11 reviews and 36 case reports and we compared their
findings about important aspects of gastric metastasis, such as disease free survival, overall survival, symptoms,
endoscopic findings, therapy, histology, and immunohistochemistry.

Background: Random biopsies are recommended to identify individuals at risk for gastric adenocarcinoma. Cumulative evidence suggests that narrow-band imaging (NBI) can be used to grade gastric intestinal metaplasia (GIM). We aimed to externally validate a classification of endoscopic grading of gastric intestinal metaplasia (EGGIM).

Main Recommendations Patients with chronic atrophic gastritis or intestinal metaplasia (IM) are at risk for gastric adenocarcinoma. This underscores the importance of diagnosis and risk stratification for these patients. High definition endoscopy with chromoendoscopy (CE) is better than high definition white-light endoscopy alone for this purpose. Virtual CE can guide biopsies for staging atrophic and metaplastic changes and can target neoplastic lesions. Biopsies should be taken from at least two topographic sites (antrum and corpus) and labelled in two separate vials.

Endoscopic submucosal dissection (ESD) allows removing neoplastic lesions on gastric
mucosa, including early gastric cancer (EGC) and dysplasia. Data on ESD from Western countries
are still scanty. We report results of ESD procedures performed in Italy. Data of consecutive patients
who underwent ESD for gastric neoplastic removal were analyzed. The en bloc resection rate and
the R0 resection rates for all neoplastic lesions were calculated, as well as the curative rate (i.e., no