Insights about the interaction of methotrexate loaded hydrophilic gold nanoparticles: spectroscopic, morphological and structural characterizations
Gold nanoparticles (AuNPs) are promising carriers in the field of nanomedicine and represent a very intriguing
approach in drug delivery applications, due to their small size and enhanced properties. This work aims to
highlight the interaction between functionalized AuNPs and the immune-system suppressant drug Methotrexate
(MTX) at molecular level. Small and monodisperse (<2RH>5 ± 1 nm) gold nanoparticles were prepared by a
simple chemical route using hydrophilic thiol 3-mercapto-1-propanesulfonate (3MPS) as a functionalizing/