Ricerc@Sapienza

Objectives:
To evaluate the impact on metabolism, bleeding, and sexual function of Nexplanon, a subdermal implant.
Study Design:

Introduction: The contraceptive activity of synthetic progestins is mediated through three basic mechanisms: (a) An anti-gonadotrophic action leading to the inhibition of ovulation; (b) Changes in cervical mucus characteristics that inhibit sperm penetration and (c) desynchronization of the endometrial picture necessary for implantation.