1The Wnt/beta-catenin pathway is often found deregulated incancer. The aberrant accumulation of beta-catenin in the cellnucleus results in the development of various malignancies. Specific drugs against this signaling pathway for clinical treat-ments have not been approved yet. Herein we report inhibitorsof beta-catenin signaling of potential therapeutic value asanticancer agents.
We discovered novel and selective sulfonamides/amides acting as inhibitors of the a-carbonic anhydrase
(CA, EC 4.2.1.1) from the pathogenic bacterium Vibrio cholerae (VchCA). This Gram-negative bacterium is
the causative agent of cholera and colonises the upper small intestine where sodium bicarbonate is present
at a high concentration. The secondary sulfonamides and amides investigated here were potent, low
nanomolar VchCA inhibitors whereas their inhibition of the human cytosolic isoforms CA I and II was in
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