Ricerc@Sapienza

The aim of this paper is to define a system to measure well-being in the European countries by using synthetic indicators. In this perspective, we adopted the framework and the methodology of the Italian project BES (Sustainable and Equitable Well-being for Italy). The project, established by the Italian Institute of Statistics and the Council of Economics and Labour, is widely considered one of the most advanced among the several projects aimed at providing the countries with measures able to support policy decision in the beyond GDP perspective.

In synthesis, assumption are constraints on the environments that rule out certain environment behaviors. A key observation is that even if we consider system with LTLf goals on finite traces, assumptions need to be expressed considering infinite traces, using LTL on infinite traces, since the decision to stop the trace is controlled by the agent. To solve synthesis of LTLf goals under LTL assumptions, we could reduce the problem to LTL synthesis.

The cholinergic pathways in the central nervous system (CNS) of animals and humans are important for cognitive and behavioural functions. Until a few years ago, it was thought that the key molecules transducing the cholinergic message were the metabotropic muscarinic receptors, but it is now known that ionotropic neuronal nicotinic receptors (nAChRs) are also involved. Based on recent studies, we prepared a small library of novel 3-substituted-3,6-diazabicyclo [3.1.1]heptanes, whose binding activity and functionality have been assayed.

We designed the synthesis of a small library of 3-substituted-3,6-diazabicyclo[3.1.1]heptanes whose affinity on neuronal nicotinic receptors (nAChRs) was evaluated. Among the synthesized compounds, the 5-(3,6-diazabicyclo[3.1.1]heptane-3-yl)-N-(2-fluorophenyl)nicotinamide 43 proved to be the most interesting compound with alpha(4)beta(2) Ki value of 10 pM and a very high alpha(7)/alpha(4)beta(2) selectivity.

We designed 3-aroyl-1,4-diarylpyrrole (ARDAP) derivatives as potential anticancer agents having different substituents at the 1- or 4-phenyl ring. ARDAP compounds exhibited potent inhibition of tubulin polymerization, binding of colchicine to tubulin, and cancer cell growth. ARDAP derivative 10 inhibited the proliferation of BCR/ABL-expressing KU812 and LAMA84 cells from chronic myeloid leukemia (CML) patients in blast crisis and of hematopoietic cells ectopically expressing the imatinib mesylate (IM)-sensitive KBM5-WT or its IM-resistant KBM5-T315I mutation.

Tetrapyrazinoporphyrazines (TPyzPzs), the heterocyclic azaanalogs of the phthalocyanine macrocycle, known since the 1930 s, but became an object of intensive studies in the last decades. In Part I (Coord. Chem. Rev. 2016, 309, 107–179) the synthesis of variously substituted TPyzPzs and their metal complexes as well as of their precursors was presented. In the present Part II, we consider the peculiarities of their electronic structure, electrochemical, spectral, acid–base and photophysical properties.

A new, relatively fast and simple synthesis of the refractory sulfide CeS using electron beam irradiation has been developed. Differently from the most common procedures involving highly reactive and/or toxic precursors such as cerium hydride and carbon disulfide, the approach here presented is based on the electron beam irradiation of pellets composed of a mixture of cerium sesquisulfide, cerium dioxide and graphite powders, i.e., nontoxic and nonreactive materials in ambient conditions that do not need any special caution during their use.