targets

Synergies between the key biodiversity area and systematic conservation planning approaches

Systematic conservation planning and Key Biodiversity Areas (KBAs) are the two most widely used approaches for identifying important sites for biodiversity. However, there is limited advice for conservation policy makers and practitioners on when and how they should be combined. Here we provide such guidance, using insights from the recently developed Global Standard for the Identification of KBAs and the language of decision science to review and clarify their similarities and differences.

Changes in human footprint drive changes in species extinction risk

Predicting how species respond to human pressure is essential to anticipate their decline and identify appropriate conservation strategies. Both human pressure and extinction risk change over time, but their inter-relationship is rarely considered in extinction risk modelling. Here we measure the relationship between the change in terrestrial human footprint (HFP)-representing cumulative human pressure on the environment-and the change in extinction risk of the world's terrestrial mammals.

Sirtuins as drug targets

The mammalian sirtuins (SIRTs) are evolutionally highly conserved proteins
and belong to class III histone deacetylases (HDACs). Its seven family members
(SIRT1–7) share a NAD+-dependent catalytic protein lysine deacetylase and/or
mono-ADP-ribosylase mechanism and are involved in various biological
processes acting on diverse substrates. SIRTs vary in length and sequence at
their N- and C-termini. This might explain in part their diverse functions and
localizations. To date, their protein lysine deacetylation is the most studied

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