In the last decade thiotaurine, 2-aminoethane thiosulfonate, has been investigated as an inflammatory modulating agent as a result of its ability to release hydrogen sulfide (H2S) known to play regulatory roles in inflammation. Thiotaurine can be included in the "taurine family" due to structural similarity to taurine and hypotaurine, and is characterized by the presence of a sulfane sulfur moiety.
Biocompatible and degradable poly(alpha-hydroxy acids) are among the more widely used materials in scaffolds for tissue engineering, although they often need surface modification to improve their interaction with the cells. In the present research Poly(L-lactide) 3D scaffold were prepared by salt-leaching method, with a porosity of 80 % and interconnected pores. In order to increase the hydrophilicity of the PLLA scaffolds surface, taurine was grafted through aminolysis reaction.
Biocompatible and degradable poly(?-hydroxy acids) are one of the most widely used materials in scaffolds for tissue engineering. Nevertheless, they often need surface modification to improve interaction with cells. Aminolysis is a common method to increase the polymer hydrophilicity and to introduce surface functional groups, able to covalently link or absorb, through electrostatic interaction, bioactive molecules or macromolecules. For this purpose, multi-functional amines, such as diethylenediamine or hexamethylenediamine are used.
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