Letter to the editors: pathogenetic analysis of sinonasal teratocarcinosarcomas reveal actionable ?-catenin overexpression and a ?-catenin mutation
We read with great interest the article “Pathogenetic Analysis of Sinonasal Teratocarcinosarcomas Reveal Actionable ?- Catenin Overexpression and a ?-Catenin Mutation” by Birkeland et al.1 In the article, the authors performed targeted exome sequencing on an index Sinonasal Teratocarcinosarcoma (SNTCS) specimen and identified an activating mutation in the ?-catenin gene (CTNNB1, c.134C > T, p.S45F). In addition, they confirmed ?-catenin overexpression and nuclear localization via immunohistochemistry in the index tumor and in a subsequent case.