Ricerc@Sapienza

Several arthropod-borne diseases are now rising with increasing impact and risks for public health, due to environmental changes and resistance to pesticides currently marketed. In addition to community surveillance programs and a careful management of herds, a next-generation of effective products is urgently needed to control the spread of these diseases, with special reference to arboviral ones. Natural product research can afford alternative solutions. Recently, a re-emerging of bluetongue disease is ongoing in Italy.

The discovery of antibiotics has revolutionized the medicine and treatment of microbial
infections. However, the current scenario has highlighted the difficulties in marketing new
antibiotics and an exponential increase in the appearance of resistant strains. On the other hand,
research in the field of drug-discovery has revaluated the potential of natural products as a unique
source for new biologically active molecules and scaffolds for the medicinal chemistry. In this