Enhancement in PDMS-Based Microfluidic Network for On-Chip Thermal Treatment of Biomolecules
In this paper, we present an improved microfluidic network based on polydimethylsiloxane (PDMS) and thin film heaters for thermal treatment of biomolecules in lab-on-chip systems. It relies on the series connection of two thermally actuated valves, at both inlet and outlet of the network, in order to reduce leakage of sample when its process temperature approaches 100, °C. The spatial arrangement of valves and microfluidic channels in between has been optimized using COMSOL Multiphysics, through the investigation of the system thermal behavior.