Ricerc@Sapienza

Gene fusions represent an important class of somatic alterations in cancer. We systematically
investigated fusions in 9,624 tumors across 33 cancer types using multiple fusion calling tools. We
identified a total of 25,664 fusions, with a 63% validation rate. Integration of gene expression,
copy number, and fusion annotation data revealed that fusions involving oncogenes tend to exhibit
increased expression, whereas fusions involving tumor suppressors have the opposite effect. For

In 2009, the four laboratories of the Fondazione Italiana Linfomi (FIL) minimal residual disease (MRD) Network started a collaborative effort to harmonize and standardize their methodologies at the national level, performing quality control (QC) rounds for follicular lymphoma (FL) and mantle cell lymphoma (MCL) MRD assessment.