Non-coding RNAs shaping muscle
In 1957, Francis Crick speculated that RNA, beyond its protein-coding capacity, could have its own function. Decade after decade this theory was dramatically boosted by the discovery of new classes of noncoding RNAs (ncRNAs), including long noncoding (lnc)RNAs and circular (circ)RNAs, which play a fundamental role in the fine spatio-temporal control of multiple layers of gene expression. Recently, many of these molecules have been identified in a plethora of different tissues and they have emerged to be more cell type specific than protein coding genes.