Ricerc@Sapienza

We performed an extensive immunogenomic analysis of more than 10,000 tumors comprising 33 diverse cancer types by utilizing data compiled by TCGA. Across cancer types, we identified six immune subtypes-wound healing, IFN-γ dominant, inflammatory, lymphocyte depleted, immunologically quiet, and TGF-β dominant-characterized by differences in macrophage or lymphocyte signatures, Th1:Th2 cell ratio, extent of intratumoral heterogeneity, aneuploidy, extent of neoantigen load, overall cell proliferation, expression of immunomodulatory genes, and prognosis.

In the last four decades, tumor immunology has shed light
on identity and functions of cells and molecules involved
in tumor rejection through the involvement of the immune
system [1]. Several groups of immune cells have been
demonstrated to be able to contrast tumor occurrence and
tumor progression by killing immunogenic tumor cells, a
phenomenon recognized under the definition of “immunosurveillance” [2]. Unfortunately, cancer may evade immunosurveillance and progress through the modifications of its