Ricerc@Sapienza

Twin studies of disease concordance are useful to weight the relative contribution of genetic and environmental factors to the cause of common complex disorders. In multiple sclerosis (MS) different twinning rates from geographic areas at different prevalence suggested that heritable and non-heritable factors contribute in different proportions and ways to MS risk in diverse populations.

Sleep electroencephalogram (EEG) has a trait-like nature. Several findings highlighted the heritability of spectral power in specific frequency ranges and sleep spindles during NREM sleep. However, a genetic influence on the K-complex (KC), one of the electrophysiological hallmarks of NREM sleep, has never been assessed. Here, we investigated the heritability of the KC detected during NREM stage 2 comparing 10 monozygotic (MZ) and 10 dizygotic (DZ) twin pairs.

The role of genes and environment in the relation between self-regulation and adjustment is unclear. We investigated, with the twin design, genetic and environmental components of the association between effortful control (EC) and indicators of psychological adjustment using adolescents’ and parents’ reports for 774 twins. Genetic factors explained a substantial proportion of variance in EC (58%) and the outcome variables of optimism (55%), general self-esteem (45%), happiness (48%), and self-derogation (29%). Perceived competence had no significant genetic component.

Objective:This study was aimed to report the incidence of neonatal morbidity in monochorionic monoamniotic (MCMA) twin pregnancies according to gestational age at birth and type of management adopted (inpatient or outpatient). Study Design ?Medline and Embase databases were searched. Inclusion criteria were nonanomalous MCMA twins.

INTRODUCTION: The aim of this systematic review was to quantify the association between birthweight discordance and neonatal morbidity in twin pregnancies. MATERIAL AND METHODS: Medline, Embase and Cinahl databases were searched. Studies reporting the occurrence of morbidity in twins affected compared to those not affected by birthweight discordance were included. The primary outcome was composite neonatal morbidity (including neurological, respiratory, infectious morbidities, abnormal acid-base status and necrotizing enterocolitis). The secondary outcomes were the individual morbidities.

PDFPDF
Tools
Share
ABSTRACT
Objectives

To report the outcomes of twin‐twin transfusion syndrome (TTTS) according to Quintero staging system.
Methods