A cell type-specific transcriptomic approach to map B cell and monocyte type I interferon-linked pathogenic signatures in multiple sclerosis
Alteration in endogenous Interferon (IFN) system may profoundly impact immune cell function in autoimmune
diseases.
Here, we provide evidence that dysregulation in IFN-regulated genes and pathways are involved in B cell- and
monocyte-driven pathogenic contribution to Multiple Sclerosis (MS) development and maintenance.
In particular, by using an Interferome-based cell type-specific approach, we characterized an increased susceptibility to an IFN-linked caspase-3 dependent apoptotic cell death in both B cells and monocytes of MS