Ricerc@Sapienza

The connection between inflammation and cancer is well-established and supported by genetic, pharmacological and epidemiological data. The inflammatory bowel diseases (IBDs), including Crohn’s disease and ulcerative colitis, have been described as important promoters for colorectal cancer development. Risk factors include environmental and food-borne mutagens, dysbalance of intestinal microbiome composition and chronic intestinal inflammation, with loss of intestinal epithelial barrier and enhanced cell proliferation rate.

Background and Aims: In ulcerative colitis (UC), inflammation begins in the rectum and
can extend proximally throughout the entire colon. The extension of inflammation is an
important determinant of disease course, and may be limited by the action of regulatory
T cells (Tregs). In this cross-sectional study, we evaluated the relationship between UC
extension and the proportions of CD3+CD4+Foxp3+ and CD3+CD4+LAP+Foxp3-
Tregs in the colonic lamina propria (LP) of 79 UC patients and 29 controls. The role of

AIM To investigate the adhesion and anti-inflammatory effects of Lactobacillus rhamnosus GG (LGG) in the colonic mucosa of healthy and ulcerative colitis (UC) patients, both in vivo and ex vivo in an organ culture model. METHODS For the ex vivo experiment, a total of 98 patients (68 UC patients and 30 normal subjects) were included.

Background: The contemporary management of ambulatory ulcerative colitis (UC) continues to be challenging with 20% of children needing a colectomy within childhood years. We thus aimed to standardize daily treatment of pediatric UC and inflammatory bowel diseases (IBD)-unclassified through detailed recommendations and practice points. Methods: These guidelines are a joint effort of the European Crohn's and Colitis Organization (ECCO) and the Paediatric IBD Porto group of European Society of Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN).

BACKGROUND:
This European Crohn's and Colitis Organisation [ECCO] topical review focuses on the transition of adolescents with inflammatory bowel disease [IBD] from child-centred to adult-oriented care. The aim was to provide evidence-supported, expert consensus for health professionals taking part in the transition.