Ricerc@Sapienza

In this work, we focused on the investigation of UV-C radiation effects on novel nanomaterials structured with graphene nanoplatelets (GNPs) and DNA. Multifunctional nanocomposites were realized by combining the good electrical conductivity of GNPs with the biocompatibility and UV sensitivity of double-stranded DNA. GNP/DNA nanostructures were prepared by sonication-driven self-assembly in aqueous solution, and then dispersed into a PEDOT:PSS (poly(3,4-ethylenedioxythiophene)-poly(styrenesulfonate)) matrix.

The use of UV-C light as a means to inactivate pathogens in biological media containing blood components or plasma derivatives has recently been rediscovered. Although highly effective, these treatments may have deleterious effects on plasma proteins such as albumin, fibrinogen and immunoglobulins. Here we investigate the use of three natural antioxidants, gallic acid, nicotinic acid and ascorbic acid, as potential stabilizers of human albumin (HA) during irradiation by UV at 254 nm.