Vimentin as a target for the treatment of COVID-19
We and others propose vimentin as a possible cellular target for the treatment of COVID-19. This innovative idea is so recent that it requires further attention and debate.
virus
An insight into the sialotranscriptome and virome of amazonian anophelines
Background: Saliva of mosquitoes contains anti-platelet, anti-clotting, vasodilatory, anti-complement and antiinflammatory
substances that help the blood feeding process. The salivary polypeptides are at a fast pace of
evolution possibly due to their relative lack of structural constraint and possibly also by positive selection on their
genes leading to evasion of host immune pressure.
Results: In this study, we used deep mRNA sequence to uncover for the first time the sialomes of four Amazonian
Nanostructure-Based Electrochemical Immunosensors as Diagnostic Tools
Electrochemical immunosensors are affinity-based biosensors characterized by several useful features such as specificity, miniaturizability, low cost and simplicity, making them very interesting for many applications in several scientific fields. One of the significant issues in the design of electrochemical immunosensors is to increase the system’s sensitivity.
SARS-CoV-2 meta-interactome suggests disease-specific, autoimmune pathophysiologies and therapeutic targets
Background: Severe coronavirus disease 2019 (COVID-19) is associated with multiple comorbidities and is characterized by an auto-aggressive inflammatory state leading to massive collateral damage. To identify preventive and therapeutic strategies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), it is important to ascertain the molecular interactions between virus and host, and how they translate into disease pathophysiology.
Il Parlamento italiano durante la crisi del coronavirus. Di chi è la responsabilità per un evidente caso di autoemarginazione?
Si tratta di un'analisi sulle modalità di lavoro del Parlamento italiano durante la crisi del coronavirus, criticate come palesemnte inadeguate
Bacillus Calmette-Guérin vaccination and socioeconomic variables vs COVID-19 global features. Clearing up a controversial issue
Since the appearance of COVID-19 in Wuhan, China, in December
2019, more than two million cases have been confirmed worldwide,
with a death toll about 140 000 by April 20, 2020. One of the puzzles
associated to the outspread of this pandemic is the geographic
variability of its outcomes in terms of incidence (IR), case fatality
(CFR), and mortality rates (MRs). Especially, striking is the case of adjacent
countries where low and high rates are recorded. Some have
suggested that such variability can be explained by the protective