Ricerc@Sapienza

Troponin I (TnI) is the inhibitory subunit of the troponin complex in the sarcomeric thin filament of striated muscle and plays a central role in the calcium regulation of contraction and relaxation. Vertebrate TnI has evolved into three isoforms encoded by three homologous genes: TNNI1 for slow skeletal muscle TnI, TNNI2 for fast skeletal muscle TnI and TNNI3 for cardiac TnI, which are expressed under muscle type-specific and developmental regulations in both the atrium and ventricle of the heart.

The purpose of this paper is to analyse the discontinuity between
animal and human birth. Starting from theories on animal instinct and those on
animal/human behaviour; from Aristotle to Darwin, and the evolutionary
synthesis of the 1940s, from distorted interpretations of Darwin’s thought to
some aspects of modern ethology and animal psychology, and the human birth
theory, the manuscript tries to respond to the old question: what differences
exist between animal behaviour and human behaviour? Trying to answer these

The vitality of an arc/node of a graph with respect to the maximum flow between two fixed nodes s and t is defined as the reduction of the maximum flow caused by the removal of that arc/node. In this paper, we address the issue of determining the vitality of arcs and/or nodes for the maximum flow problem. We show how to compute the vitality of all arcs in a general undirected graph by solving only 2(n − 1) max flow instances and, in st‐planar graphs (directed or undirected) we show how to compute the vitality of all arcs and all nodes in O(n) worst‐case time.