Ricerc@Sapienza

In treating head and neck cancer (HNC), the objectives are provided for best functional results and minimal risk of serious complications. The choice of appropriate management depends primarily on specific site and stage of primary tumor at diagnosis. Radiation therapy (RT) with or without concomitant chemotherapy represents a classical treatment option. In this review, we provide an update of recent research strategies to counteract the existing damage caused by RT and highlight clinical trials currently in progress.

We study the asymptotic behavior of simply connected Riemannian manifolds X of strictly negative curvature admitting a non-uniform lattice Γ. If the quotient manifold X = Γ\X is asymptotically 1=4-pinched, we prove that Γ is divergent and U X has finite Bowen-Margulis measure (which is then ergodic and totally conservative with respect to the geodesic flow); moreover, we show that, in this case, the volume growth of balls B(x,R) in X is asymptotically equivalent to a purely exponential function c.x/eδR, where δ is the topological entropy of the geodesic flow of X .