Ricerc@Sapienza

A promising field of application of the X-ray radiation generated by intense laser-matter interaction is the contact-microscopy of biological samples. In order to optimize the yield on the desired spectral window, it is fundamental to have an accurate characterization of this emitted radiation. To this purpose, an experimental campaign is underway with the three-nanosecond phosphate Nd:glass laser at the ABC laboratory in ENEA. The plasma was generated by irradiating solid targets with energy up to 30 J, and intensity on target up to 1014 Wcm−2.

The recent interest in ?? radionuclides for radio-guided surgery derives from the feature of the ? radiation to release energy in few millimeters of tissue. Such feature can be used to locate residual tumors with a probe located in its immediate vicinity, determining the resection margins with an accuracy of millimeters. The drawback of this technique is that it does not allow to identify tumors hidden in more than few mm of tissue. Conversely, the bremsstrahlung X-rays emitted by the interaction of the ?? radiation with the nuclei of the tissue are relatively penetrating.