Ricerc@Sapienza

UDP-glucose:glycoprotein glucosyltransferase (UGGT) flags misfolded glycoproteins for ER retention. We report crystal structures of full-length Chaetomium thermophilum UGGT (CtUGGT), two CtUGGT double-cysteine mutants, and its TRXL2 domain truncation (CtUGGT-ΔTRXL2). CtUGGT molecular dynamics (MD) simulations capture extended conformations and reveal clamping, bending, and twisting inter-domain movements.

We explore the structure of a series of protic Ionic Liquids based on the choline cation and amino acid anions. In the series, the length and the branching of the amino acid alkyl chain varies. Ab initio molecular dynamics, X-ray diffraction measurements, and infrared spectra have been used to provide a reliable picture of the short-range structure and of the short-time dynamic process that characterize the fluids. We have put special emphasis on the peculiar and complicated network of hydrogen bonds that stem from the amphoteric nature of the anion moiety.

The quest for sustainable chemistry is fortunately an unstoppable process, and a new class of
biodegradable compounds, the Deep Eutectic Solvents (DES) [1,2], has recently been proposed as
inexpensive and “greener” alternative to flank the family of solvents currently considered the “pillar” of
solution green chemistry—ionic liquids. Such a new class is composed of an eutectic mixture of
solids, usually the quaternary ammonium salt choline chloride, and a hydrogen-donor (HBD) Brønsted

Phoenician expansion spread all over the Mediterranean coast and came together with the foundation of new
colonies. Red Slip Ware, a ceramic class characterized by a shiny deep red surface, seems to be a good marker to
identify and to date the early Phoenician presence on the territory. Indeed, Red Slip Ware is found in every Phoenician
site, from the motherland to the colonies. Representative fragments of Red Slip Ware from the Phoenician-Punic site of