Critical role of Phosphodiesterase 2A in mouse congenital heart defects

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Assenza MARIA RITA, Barbagallo Federica, Barrios Florencia, Cornacchione Marisa, Campolo Federica, Vivarelli Elisabetta, Gianfrilli Daniele, Auletta Luigi, Soricelli Andrea, Isidori Andrea, Lenzi Andrea, Pellegrini Manuela, Naro Fabio.
ISSN: 1755-3245

Phosphodiesterase 2A, a cAMP-hydrolysing enzyme, is essential for mouse development, however the cause of Pde2A knockout embryonic lethality is unknown. To understand if Pde2A plays a role in cardiac development, hearts of Pde2A deficient embryos were analysed at different stage of development.

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