A call for a better understanding of causation in cell biology
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Bizzarri Mariano, Brash Douglas E., Briscoe James, Grieneisen Verônica A., Stern Claudio D., Levin Michael
ISSN: 1471-0072
What does it mean to say that event X caused outcome Y in biology? Explaining the causal
structure underlying the dynamic function of living systems is a central goal of biology.
Transformative advances in regenerative medicine and synthetic bioengineering will require
efficient strategies to cause desired system- level outcomes. We present a perspective on the
need to move beyond the classical ‘necessary and sufficient’ approach to biological causality