Synthesis of heterohelicenes by a catalytic multi-component povarov reaction
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Viglianisi Caterina, Biagioli Chiara, Lippi Martina, Pedicini Maria, Villani Claudio, Franzini Roberta, Menichetti Stefano
ISSN: 1434-193X
A multi-component Povarov reaction was used for the preparation of [4], [5] and [6]aza- and azaoxahetero helical-shaped compounds. The oxidation of the tetrahydroquinolinic primary Povarov adducts to the aromatic quinolines is mandatory to achieve a helical-shaped structure and can be carried out in a one-pot fashion with DDQ. Resolution of [5] and [6]heterohelicenes was successfully performed by chiral HPLC.