Levodopa may affect cortical excitability in Parkinson's disease patients with cognitive deficits as revealed by reduced activity of cortical sources of resting state electroencephalographic rhythms
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Babiloni Claudio, Del Percio Claudio, Lizio Roberta, Noce Giuseppe, Lopez Susanna, Soricelli Andrea, Ferri Raffaele, Pascarelli Maria Teresa, Catania Valentina, Nobili Flavio, Arnaldi Dario, Famà Francesco, Orzi Francesco, Buttinelli Carla, Giubilei Franco, Bonanni Laura, Franciotti Raffaella, Onofrj Marco, Stirpe Paola, Fuhr Peter, Gschwandtner Ute, Ransmayr Gerhard, Fraioli Lucia, Parnetti Lucilla, Farotti Lucia, Pievani Michela, D'Antonio Fabrizia, De Lena Carlo, Güntekin Bahar, Hanoğlu Lutfu, Yener Görsev, Emek-Savaş Derya Durusu, Triggiani Antonio Ivano, Taylor John Paul, McKeith Ian, Stocchi Fabrizio, Vacca Laura, Frisoni Giovanni B., De Pandis Maria Francesca
ISSN: 0197-4580
We hypothesized that dopamine neuromodulation might affect cortical excitability in Parkinson's disease (PD) patients set in quiet wakefulness, as revealed by resting state eyes-closed electroencephalographic (rsEEG) rhythms at alpha frequencies (8–12 Hz). Clinical and rsEEG rhythms in PD with dementia (N = 35), PD with mild cognitive impairment (N = 50), PD with normal cognition (N = 35), and normal (N = 50) older adults were available from an international archive. Cortical rsEEG sources were estimated by exact low-resolution brain electromagnetic tomography. Compared with the normal older group, the PD groups showed reduced occipital alpha sources and increased widespread delta (