Cavedo Enrica, Chiesa Patrizia A., Houot Marion, Ferretti Maria Teresa, Grothe Michel J., Teipel Stefan J., Lista Simone, Habert Marie-Odile, Potier Marie-Claude, Dubois Bruno, Hampel Harald, Bakardjian Hovagim, Benali Habib, Bertin Hugo, Bonheur Joel, Boukadida Laurie, Boukerrou Nadia, Cavedo Enrica, Chiesa Patrizia, Colliot Olivier, Dubois Bruno, Dubois Marion, Epelbaum Stéphane, Gagliardi Geoffroy, Genthon Remy, Habert Marie-Odile, Hampel Harald, Houot Marion, Kas Aurélie, Lamari Foudil, Levy Marcel, Lista Simone, Metzinger Christiane, Mochel Fanny, Nyasse Francis, Poisson Catherine, Potier Marie-Claude, Revillon Marie, Santos Antonio, Andrade Katia Santos, Sole Marine, Surtee Mohmed, de Schotten Michel Thiebaud, Vergallo Andrea, Younsi Nadjia, Aguilar Lisi Flores,
Babiloni Claudio, Baldacci Filippo, Benda Norbert, Black Keith L., Bokde Arun L. W., Bonuccelli Ubaldo, Broich Karl, Bun René S., Cacciola Francesco, Castrillo Juan, Cavedo Enrica, Ceravolo Roberto, Chiesa Patrizia A., Colliot Olivier, Coman Cristina-Maria, Corvol Jean-Christophe, Cuello Augusto Claudio, Cummings Jeffrey L., Depypere Herman, Dubois Bruno, Duggento Andrea, Durrleman Stanley, Escott-Price Valentina, Federoff Howard, Ferretti Maria Teresa, Fiandaca Massimo, Frank Richard A., Garaci Francesco, Genthon Remy, George Nathalie, Giorgi Filippo S.,
Graziani Manuela, Haberkamp Marion, Habert Marie-Odile, Hampel Harald, Herholz Karl, Karran Eric, Kim Seung H., Koronyo Yosef, Koronyo-Hamaoui Maya, Lamari Foudil, Langevin Todd, Lehéricy Stéphane, Lista Simone, Lorenceau Jean, Mapstone Mark, Neri Christian, Nisticò Robert, Nyasse-Messene Francis, O'Bryant Sid E., Perry George, Ritchie Craig, Rojkova Katrine, Rossi Simone, Saidi Amira, Santarnecchi Emiliano, Schneider Lon S., Sporns Olaf, Toschi Nicola, Verdooner Steven R., Vergallo Andrea, Villain Nicolas, Welikovitch Lindsay A., Woodcock Janet, Younesi Erfan
Introduction: Observational multimodal neuroimaging studies indicate sex differences in Alzheimer's disease pathophysiological markers. Methods: Positron emission tomography brain amyloid load, neurodegeneration (hippocampus and basal forebrain volumes adjusted to total intracranial volume, cortical thickness, and 2-deoxy-2-[fluorine-18]fluoro-D-glucose–positron emission tomography metabolism), and brain resting-state functional connectivity were analyzed in 318 cognitively intact older adults from the INSIGHT-preAD cohort (female n = 201, male n = 117). A linear mixed-effects model was performed to investigate sex effects and sex∗apolipoprotein E genotype interaction on each marker as well as sex∗amyloid group interaction for non-amyloid markers. Results: Men compared with women showed higher anterior cingulate cortex amyloid load (P =.009), glucose hypometabolism in the precuneus (P =.027), posterior cingulate (P <.001 and="" inferior="" parietal="" cortices="" lower="" resting-state="" functional="" connectivity="" in="" the="" default="" mode="" network="" no="" brain="" volumetric="" markers="" showed="" differences="" between="" men="" women.="" sex="" e="" genotype="" status="" interactions="" were="" not="" significant.="" discussion:="" our="" findings="" suggest="" that="" cognitively="" intact="" older="" compared="" with="" women="" have="" higher="" resilience="" to="" pathophysiological="" processes="" of="" alzheimer="" disease.="">
