J. M. Bas-Hoogendam, N. A. Groenewold, M. Aghajani, G. F. Freitag, A. Harrewijn, K. Hilbert, N. Jahanshad, S. I. Thomopoulos, P. M. Thompson, D. J. Veltman, A. M. Winkler, U. Lueken, D. S. Pine, N. J. A. van der Wee, Federica Agosta Stein D. J., Åhs Fredrik, An Iseul, Alberton Bianca A. V., Andreescu Carmen, Asami Takeshi, Assaf Michal, Avery Suzanne N., Balderston Nicholas L., Barber Jacques P., Battaglia Marco, Bayram Ali, Beesdo‐Baum Katja, Benedetti Francesco, Berta Rachel, Björkstrand Johannes, Urbano Blackford Jennifer, Blair James R., Blair Karina S., Boehme Stephanie, Brambilla Paolo, Burkhouse Katie, Cano Marta, Canu Elisa, Cardinale Elise M., Cardoner Narcis, Clauss Jacqueline A., Cividini Camilla, Critchley Hugo D., Dannlowski Udo, Deckert Jurgen, Demiralp Tamer, Diefenbach Gretchen J., Domschke Katharina, Doruyter Alex, Dresler Thomas, Erhardt Angelika, Fallgatter Andreas J., Fañanás Lourdes, Feola Brandee, Filippi Courtney A., Filippi Massimo, Fonzo Gregory A., Forbes Erika E., Fox Nathan A., Fredrikson Mats, Furmark Tomas, Ge Tian, Gerber Andrew J., Gosnell Savannah N., Grabe Hans J., Grotegerd Dominik, Gur Raquel E., Gur Ruben C., Harmer Catherine J., Harper Jennifer, Heeren Alexandre, Hettema John, Hofmann David, Hofmann Stefan G., Jackowski Andrea P., Jansen Andreas, Kaczkurkin Antonia N., Kingsley Ellen, Kircher Tilo, Kostić Milutin, Kreifelts Benjamin, Krug Axel, Larsen Bart, Lee Sang‐Hyuk, Leehr Elisabeth J., Leibenluft Ellen, Lochner Christine, Maggioni Eleonora, Makovac Elena, Mancini Matteo, Manfro Gisele G., Månsson Kristoffer N. T., Meeten Frances, Michałowski Jarosław, Milrod Barbara L., Mühlberger Andreas, Mujica‐Parodi Lilianne R., Munjiza Ana, Mwangi Benson, Myers Michael, Nenadić Igor, Neufang Susanne, Nielsen Jared A., Oh Hyuntaek,
Ottaviani Cristina, Pan Pedro M., Pantazatos Spiro P., Paulus Martin P., Perez‐Edgar Koraly, Peñate Wenceslao, Perino Michael T., Peterburs Jutta, Pfleiderer Bettina, Luan Phan K., Poletti Sara, Porta‐Casteràs Daniel, Price Rebecca B., Pujol Jesus, Reinecke Andrea, Rivero Francisco, Roelofs Karin, Rosso Isabelle, Saemann Philipp, Salas Ramiro, Salum Giovanni A., Satterthwaite Theodore D., Schneier Franklin, Schruers Koen R. J., Schulz Stefan M., Schwarzmeier Hanna, Seeger Fabian R., Smoller Jordan W., Soares Jair C., Stark Rudolf, Stein Murray B., Straube Benjamin, Straube Thomas, Strawn Jeffrey R., Suarez‐Jimenez Benjamin, Suchan Boris, Sylvester Chad M., Talati Ardesheer, Tamburo Erica, Tükel Raşit, van den Heuvel Odile A., Van der Auwera Sandra, van Nieuwenhuizen Helena, van Tol Marie‐José, van Velzen Laura S., Ventura Bort Carlos, Vermeiren Robert R. J. M., Visser Renee M., Volman Inge, Wannemüller Andre, Wendt Julia, Werwath Kathryn E., Michiel Westenberg P., Wiemer Julian, Wittfeld Katharina, Wu Mon‐Ju, Yang Yunbo, Zilverstand Anna, Zugman Andre, L. Zwiebel. Hannah
Anxiety disorders are highly prevalent and disabling but seem particularly tractable to investigation with translational neuroscience methodologies. Neuroimaging has informed our understanding of the neurobiology of anxiety disorders, but research has been limited by small sample sizes and low statistical power, as well as heterogenous imaging methodology. The ENIGMA-Anxiety Working Group has brought together researchers from around the world, in a harmonized and coordinated effort to address these challenges and generate more robust and reproducible findings. This paper elaborates on the concepts and methods informing the work of the working group to date, and describes the initial approach of the four subgroups studying generalized anxiety disorder, panic disorder, social anxiety disorder, and specific phobia. At present, the ENIGMA-Anxiety database contains information about more than 100 unique samples, from 16 countries and 59 institutes. Future directions include examining additional imaging modalities, integrating imaging and genetic data, and collaborating with other ENIGMA working groups. The ENIGMA consortium creates synergy at the intersection of global mental health and clinical neuroscience, and the ENIGMA-Anxiety Working Group extends the promise of this approach to neuroimaging research on anxiety disorders.
