Distinguishing features between patients with acute diverticulitis and diverticular bleeding: Results from the REMAD registry

2021

DIGESTIVE AND LIVER DISEASE

Distinguishing features between patients with acute diverticulitis and diverticular bleeding: Results from the REMAD registry

01 Pubblicazione su rivista

Carabotti M, Morselli Labate AM, Cremon C, Cuomo R, Pace F, Andreozzi P, Falangone F, Barbara G, Annibale B, Alida Andrealli, Angelo Andriulli, Sandro Ardizzone, Marco Astegiano, Francesco Bachetti, Simona Bartolozzi, Stefano Bargiggia, Gabrio Bassotti, Maria Antonia Bianco, Gian Andrea Binda, Giuseppe Biscaglia, Matteo Bosani, Maria Erminia Bottiglieri, Martina Cargiolli, Carolina Ciacci, Antonio Colecchia, Alessandra Dell’Era, Marina De Matthaeis, Agostino Di Ciaula, Mirko Di Ruscio, Marco Dinelli, Virginia Festa, Davide Festi, Ermenegildo Galliani, Bastianello Germana’, Mario Grassini, Ennio Guido, Iafrate Franco, Paola Iovino, Donato Iuliano, Laghi Andrea, Giovanni Latella, Giampiero Manes, Elisa Marabotto, Santino Marchi, Bi-agio Mauro, Attilio Maurano, Alessandro Moscatelli, Riccardo Nascimbeni, Matteo Neri, Pietro Occhipinti, Marco Parravicini, Marco Pennazio, Sergio Peralta, Piero Portincasa, Franco Radaelli, Raffaella Reati, Alessandro Redaelli, Marco Rossi, Raffale Salerno, Vincenzo Savarino, Sergio Segato, Severi Carola, Giuseppe Scaccianoce, Paolo Usai, Valentina Valle, Clara Virgilio.

DOI: 10.1016/j.dld.2020.05.045

ISSN: 1590-8658

Background: Pathogenesis of acute diverticulitis and diverticular bleeding remains poorly defined, and few data compare directly risk factors for these complications.

Aims: to assess differences in clinical features, lifestyles factors and concurrent drug use in patients with acute diverticulitis and those with diverticular bleeding.

Methods: Data were obtained from the REMAD Registry, an ongoing 5-year prospective, observational, multicenter, cohort study conducted on 1,217 patients. Patient- and clinical- related factors were compared among patients with uncomplicated diverticular disease, patients with previous acute diverticulitis, and patients with previous diverticular bleeding.

Results: Age was significantly lower (OR 0.48, 95% CI: 0.34-0.67) and family history of diverticular disease was significantly higher (OR 1.60, 95% CI: 1.11-2.31) in patients with previous diverticulitis than in patients with uncomplicated diverticular disease, respectively. Chronic obstructive pulmonary disease was significantly higher in patients with previous diverticular bleeding as compared with both uncomplicated diverticular disease (OR 8.37, 95% CI: 2.60-27.0) and diverticulitis (OR 4.23, 95% CI: 1.11-16.1).

Conclusion: This ancillary study from a nationwide Registry showed that some distinctive features identify patients with acute diverticulitis and diverticular bleeding. These information might improve the assessment of risk factors for diverticular complications.

Diverticular complications Diverticular Diseases