Ricerc@Sapienza

Objective: It's controversial if Behcet Disease (BD) must be included in the group of seronegative spondyloarthropathy (SpA). Our
aim was to establish the prevalence of sacroiliitis (SI) in patients with BD using X-Ray, CT and MRI, in comparison with patients with
Acute Anterior Uveitis (AAU), that is known to belong to the subgroups of SpA.
Methods: We considered, in the period from 04/2006 to 04/2009, 21 consecutive patients with BD, positive for HLA B51 and 28
consecutive patients with AAU, positive for HLA B27. These patients were previously selected by our Rheumatological Ward.
Altogether we evaluated 98 sacroiliac joints (SIJ); each side of any patient was graded separately.
Results: X-ray of the pelvis showed advanced SI (grade 4) in 14% of the cases in patients with AAU; in BD group only 7% CT
showed advanced SI in 14% within AAU patients versus 6-12% of advanced SI (right to left) within BD patients. MR showed 14%
of advanced SI (bilateral) within AAU versus 6-11% of advanced SI (right to left) in BD patients.
Conclusions: This study supports the trend to not consider BD within the SpA, being the prevalence of SI in BD patients not very
different from general population and anyway lower than that observed in patients with AAU. On the other side the prevalence of
SI in AAU patients is higher than in BD patients and very similar to the one observed in patients with seronegative arthritis, and
anyway high enough to consider joint involvement as an important feature of the disease.