Critical role of Phosphodiesterase 2A in mouse congenital heart defects
01 Pubblicazione su rivista
Assenza MARIA RITA, Barbagallo Federica, Barrios Florencia, Cornacchione Marisa, Campolo Federica, Vivarelli Elisabetta, Gianfrilli Daniele, Auletta Luigi, Soricelli Andrea, Isidori Andrea, Lenzi Andrea, Pellegrini Manuela, Naro Fabio.
DOI: 10.1093/cvr/cvy030
ISSN: 1755-3245
Phosphodiesterase 2A, a cAMP-hydrolysing enzyme, is essential for mouse development, however the cause of Pde2A knockout embryonic lethality is unknown. To understand if Pde2A plays a role in cardiac development, hearts of Pde2A deficient embryos were analysed at different stage of development.