Effect of low or high doses of low‐molecular‐weight heparin on thrombin generation and other haemostasis parameters in critically ill patients with COVID‐19
01 Pubblicazione su rivista
Chistolini Antonio, Ruberto Franco, Alessandri Francesco, Santoro Cristina, Barone Francesco, Cristina Puzzolo Maria, Ceccarelli Giancarlo, De Luca Maria L., Mancone Massimo, Alvaro Domenico, Pulcinelli Fabio M., Martelli Maurizio, Foà Robin, Pugliese Francesco, Albante Alida, Alessandri Francesco, Alvaro Domenico, Antonelli Guido, Araimo‐Morselli Fabio, Auricchio Daniela, Baldacci Erminia, Barone Francesco, Bilotta Federico, Brisciani Matteo, Bruno Katia, Cappannoli Alessandro, Cardinale Vincenzo, Ceccarelli Giancarlo, Celli Paola, Chistolini Antonio, Consolo Stella, Croce Claudia, Crocitti Beatrice, Curreli Mariaignazia, D'Ettorre Gabriella, De Lauri Daniela, De Lazzaro Francesco, De Luca Maria Lucia, Fedele Francesco, Ferretti Antonietta, Galardo Gioacchino, Giannetti Lorena, Ianni Stefano, Imperiale Carmela, Maestrini Viviana, Magnanimi Eugenia, Maldarelli Federica, Mancone Massimo, Martelli Maurizio, Martelli Sabina, Mastroianni Claudio, Messina Teresa, Olivieri Sandra, Pallotta Agnese, Pattelli Elisa, Pecorari Filippo, Perrella Serena, Piazzolla Mario, Portieri Monica, Pugliese Francesco, Pulcinelli Fabio, Ratini Fabiola, Ricci Claudia, Ruberto Franco, Santopietro Pietro, Santoro Cristina, Serrao Alessandra, Tellan Guglielmo, Titi Luca, Tordiglione Paolo, Tosi Antonella, Trigilia Fausto
DOI: 10.1111/bjh.17003
ISSN: 0007-1048
The clinical picture of the severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2)/coronavirus disease 2019 (COVID‐19)‐related acute respiratory syndrome is often associated with a coagulopathy.1 An elevated D‐dimer has been linked with an unfavourable prognosis in patients with COVID‐19. In a recent cohort study, 71% of patients who died matched the International Society of Thrombosis and Hemostasis (ISTH) criteria for disseminated intravascular coagulation (DIC)2, while this percentage was only 0·6% in patients who survived.