Interferon lambda4 polymorphism is not associated with human papillomavirus infection outcome
01 Pubblicazione su rivista
Cannella Fabiana, Scagnolari Carolina, Statzu Maura, Sciandra Ilaria, Recine Nadia, D’Ettorre Gabriella, Antonelli Guido, Pierangeli Alessandra
ISSN: 0920-8569
Interferon (IFN) lambdas are important specific components of the mucosal innate immune response. The IFN lambda 4 (IFNL4) dinucleotide polymorphism (ΔG/TT) determines the IFN lambdas and related Interferon-stimulated genes activation, in HCV and other chronic infections. Our group first reported that IFN Lambda response was impaired in high-risk Human Papillomavirus (HPV) cervical infections and in precancerous lesions. Accordingly, we sought to evaluate the possible role of the IFNL4 polymorphism in determining HPV infection outcome. The ΔG/TT alleles were not differently distributed in 221 women with high- or low-risk HPV infection, with HPV infection clearance or persistence, and with abnormal cytology.