Deoxycorticosterone acetate-salt hypertension activates placental growth factor in the spleen to couple sympathetic drive and immune system activation.
01 Pubblicazione su rivista
Perrotta Marialuisa, Lori Andrea, Carnevale Lorenzo, Fardella Stefania, Cifelli Giuseppe, Iacobucci Roberta, Mastroiacovo Francesco, Iodice Daniele, Pallante Fabio, Storto Marianna, Lembo Giuseppe, Carnevale Daniela
DOI: 10.1093/cvr/cvy001
ISSN: 0008-6363
Chronic increase of mineralocorticoids obtained by administration of Deoxycorticosterone acetate (DOCA) results in salt dependent hypertension in animals. Despite the lack of a generalized sympathoexcitation, DOCA-salt hypertension has been also associated to overdrive of peripheral nervous system in organs typically targeted by blood pressure (BP), as kidneys and vasculature. Aim of this study was to explore whether DOCA-salt recruits immune system by overactivating sympathetic nervous system in lymphoid organs and whether this is relevant for hypertension.