Matrisome analysis of intrahepatic cholangiocarcinoma unveils a peculiar cancer-associated extracellular matrix structure
01 Pubblicazione su rivista
Carpino Guido, Overi Diletta, Melandro Fabio, Grimaldi Alessio, Cardinale Vincenzo, Di Matteo Sabina, Mennini Gianluca, Rossi Massimo, Alvaro Domenico, Barnaba Vincenzo, Gaudio Eugenio, Mancone Carmine
ISSN: 1559-0275
Intrahepatic cholangiocarcinoma (iCCA) is a malignancy that arises from the intrahepatic biliary tree, showing high mortality rates due to its late clinical presentation and limited treatment options. iCCA is characterized by a dense, reactive desmoplastic stroma marked by a dramatic accumulation of extracellular matrix (ECM). Although recent results strongly suggest a relationship between increasing desmoplastic stroma and the enhanced malignant behaviour of iCCA, the importance of ECM proteins in the pathogenesis of iCCA still have to be addressed.