Ricerc@Sapienza

The electromagnetic fields application as a way to enhance biomedical techniques has recently drawn the attention of the scientific community, together with the possibility to use biocompatible nanocarriers to safely transport therapeutic substances along the body. For this reason, microdosimetric studies represent a fundamental tool to deeply understand biological effects and improve drug delivery nanosystems methods. With this regard, the behaviour of liposomes, biological vesicles with a bilayered membrane similar to cell membrane, are often under investigation in order to both use them as electromagnetic fields triggerable nanocarriers and as simple model able to mimick cellular membrane response. In this work, 2D microdosimetric analyses on single liposomal vesicles, with different dimensions from the nanometer to the micrometer scale, have been carried out studying the feasibility to increase biological membrane permeability through radiofrequency fields signals. At the end, the response of a 2D model of 142 randomly placed nanosized liposomes has been proposed as a more realistic drug delivery systems suspension.