Inflammatory signatures in older persons with physical frailty and sarcopenia. the frailty "cytokinome" at its core
01 Pubblicazione su rivista
Marzetti Emanuele, Picca Anna, Marini Federico, Biancolillo Alessandra, Coelho-Junior Hélio José, Gervasoni Jacopo, Bossola Maurizio, Cesari Matteo, Onder Graziano, Landi Francesco, Bernabei Roberto, Calvani Riccardo
ISSN: 0531-5565
The construct of physical frailty and sarcopenia (PF&S) identifies an age-related pre-disability condition defined by reduced physical performance and low muscle mass. Whether PF&S is characterized by perturbations of the cytokine network is presently unclear. Furthermore, the existence of gender-specific inflammatory profiles of PF&S is unknown. This study was designed to explore the association between a large panel of inflammatory biomolecules and PF&S in older adults through a multivariate statistical approach. Gender-specific inflammatory patterns were also explored.