Tetrasubstituted cyclopentadienones as suitable enantiopure ligands with axial chirality.
01 Pubblicazione su rivista
Prati L., Mancinelli M., Ciogli Alessia, Mazzanti A.
DOI: 10.1039/c7ob01455d
ISSN: 1477-0520
A series of thermally stable atropisomeric phencyclone ligands (?G‡
rac > 35 kcal mol?1), bearing two chiral
axes, has been successfully synthesized, taking into account the results of DFT calculations on model
systems. The absolute configurations of the novel atropisomers have been assigned using TD-DFT simulation
of ECD spectra. Atropisomeric phencyclones herein presented pave the way towards new ruthenium-
based enantioselective hydrogenation catalysts