Design of hybrid gels based on gellan-cholesterol derivative and P90G liposomes for drug depot applications
01 Pubblicazione su rivista
Zoratto Nicole, Palmieri Francesca Romana, Cencetti Claudia, Montanari Elita, DI MEO Chiara, Manca Maria Letizia, Manconi Maria, Matricardi Pietro
DOI: 10.3390/gels3020018
ISSN: 2310-2861
Gels are extensively studied in the drug delivery field because of their potential benefits in therapeutics. Depot gel systems fall in this area, and the interest in their development has been focused on long-lasting, biocompatible, and resorbable delivery devices. The present work describes a new class of hybrid gels that stem from the interaction between liposomes based on P90G phospholipid and the cholesterol derivative of the polysaccharide gellan. The mechanical properties of these gels and the delivery profiles of the anti-inflammatory model drug diclofenac embedded in such systems confirmed the suitability of these hybrid gels as a good candidate for drug
depot applications.