Ricerc@Sapienza

Endovascular repair of descending thoracic aorta (DTA) is considered as first interventional option for most part of the aortic disorders. However,
many unmet needs and issues are still limiting its applicability. One of the major limitations is related to the existing gaps in evidence. Clear
and robust evidence is still needed in many aspects of the management of DTA pathologies. In numerous clinical scenarios, adequate trials are
lacking. Besides those gaps in evidence, it is well recognized that thoracic endografting (TEVAR) is technically evolving in order to overcome
technical and device-related complications and limitations. We can deploy endografts in any aortic segment: in the descending, in the ascending,
in the arch, even preserving aortic branches. Nevertheless, from the pure technical point of view, current generations of endografts still need
more development and improvement. Durability remains the major concern for any endovascular treatment, and thoracic endografting is not an
exception. As Galenus said, the physician is only nature’s assistant, thoracic endograft should also follow the natural anatomy instead of fighting
against it. We will focus the following pages on the graft conformability and compliance, both related to durability and safety of thoracic
endografting. We will review the current knowledge and concerns associated with the anatomical and hemodynamic modifications induced by
the thoracic endograft strength, stiffness and straightness and their implications for the future thoracic endograft designs.