Heroin versus cocaine: opposite choice as a function of context but not of drug history in the rat

01 Pubblicazione su rivista
De Luca Maria Teresa, Montanari Christian, Meringolo Maria, Contu Laura, Celentano Michele, Badiani Aldo
ISSN: 1432-2072

Previous studies have shown that rats trained to self-administer heroin and cocaine exhibit opposite preferences, as a function of setting, when tested in a choice paradigm. Rats tested at home prefer heroin to cocaine, whereas rats tested outside the home prefer cocaine to heroin. Here, we investigated whether drug history would influence subsequent drug preference in distinct settings. Based on a theoretical model of drug-setting interaction, we predicted that regardless of drug history rats would prefer heroin at home and cocaine outside the home.

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