Protective effects of 4-methylcoumarins and related compounds as radical scavengers and chain-breaking antioxidants
01 Pubblicazione su rivista
Kancheva V. D., Slavova-Kazakova A. K., Angelova S. E., Singh S. K., Malhotra S., Singh B. K., Saso L., Prasad A. K., Parmar V. S.
ISSN: 1638-6183
The aim of this study is to determine, and to compare the protective effects of eight 4-methylcoumarins and four related compounds as radical scavengers and chain-breaking antioxidants. The main kinetic parameters of their radical scavenging activity (as % RSA, stoichiometry, n, and rate constants of reaction with DPPH radical, kRSA) and of chain breaking antioxidant activity (as antioxidant efficiency, PF and reactivity, ID), have been determined and discussed. The RSA study has been conducted at physiological temperature (37 °?) towards DPPH radical and the tested compounds are separated into three main groups: with strong activity (% RSA > 40%); with moderate activity (20% 40%) and with weak activity (% RSA