New insights in the antitumor effects of β-caryophyllene in breast cancer cells: The role of cannabinoid and adrenergic systems
04 Pubblicazione in atti di convegno
Di Sotto A., Romaniell D., Freddoni G., Abete L., Cocchiola R., Di Giacomo S., Altieri F., Mazzanti G., Eufemi M.
ISSN: 0923-7534
Triple-negative breast cancer (TNBC) is an aggressive disease, with poor therapeutic alternatives, whose incidence and mortality seem to be increased by smoking habit. In line with our previous evidence (Di Giacomo et al. Food Chem Toxicol 2018,111:393), we evaluated the antitumor properties of the natural sesquiterpene β-caryophyllene (CRY) in triple negative breast cancer as a possible novel targeted therapeutic strategy. Particularly, its effect on the molecular pathways of STAT3 and IL-8, and the involvement of cannabinoid and β2-adrenergic systems, whose control on cell proliferation has been reported, were studied.