Does Hormone Replacement Therapy Impact the Prognosis in Endometrial Cancer Survivors? A Systematic Review
Purpose: The objective of this study was to evaluate the impact of hormone replacement therapy (HRT) on the prognosis
in endometrial cancer (EC) survivors. Methods: The research was conducted using the following electronic databases:
MEDLINE (PubMed), Web of Science, ClinicalTrial.gov, and Cochrane Library. We performed a review of studies
published from January 1986 to January 2019. We selected studies that included EC patients submitted to surgery with
curative intent and postoperative use of HRT. Result: Seven of 1,332 abstracts considered were eligible: 4 retrospective
series, 1 prospective study, 1 randomized controlled trial, and 1 population study. Globally in the observed studies
there was not a significant increase in the recurrence rate, measured by the relative risk, in the EC survivors using HRT
compared with the controls in tumour stages I and II. The bias was that HRT was prescribed only to low-risk patients,
who were young and had a low stage of disease. Conclusion: This systematic review shows that HRT use had no negative
effect on prognosis in EC survivors in tumour stages I and II.