DCLK1, a putative novel stem cell marker in human cholangiocarcinoma
01 Pubblicazione su rivista
Nevi Lorenzo, Di Matteo Sabina, Carpino Guido, Zizzari Ilaria, Safarikia Samira, Ambrosino Valeria, Costantini Daniele, Overi Diletta, Giancotti Antonella, Monti Marco, Bosco Daniela, De Peppo Valerio, Oddi Andrea, De Rose Agostino Maria, Melandro Fabio, Bragazzi Maria Consiglia, Faccioli Jessica, Massironi Sara, Grazi Gian Luca, Panici Pierluigi Benedetti, Berloco Paquale Bartomeo, Giuliante Felice, Cardinale Vincenzo, Invernizzi Pietro, Caretti Giuseppina, Gaudio Eugenio, Alvaro Domenico
DOI: 10.1002/hep.31571
ISSN: 0270-9139
Cholangiocarcinoma (CCA) is a very aggressive cancer showing high cancer stem cells (CSCs) presence. Doublecortin-like kinase1 (DCLK1) has been demonstrated as a CSC marker in different gastroenterological solid tumours. Our aim was to evaluate in vitro the expression and the biological function of DCLK1 in intrahepatic CCA (iCCA) and perihilar CCA (pCCA).