HPV-related vulvar diseases and perspectives of p16INK4a immunochemistry: a review of the literature
01 Pubblicazione su rivista
Carrone Angela, Riganelli Lucia, Savone Delia, Casorelli Assunta, Merlino Lucia, Pecorini Francesco, Pecorella Irene, Mancino Pasquale, Piccioni Maria Grazia, Benedetti Panici Pierluigi
DOI: 10.5301/tj.5000642
ISSN: 0300-8916
Two different types of vulvar intraepithelial neoplasia (VIN), HPV-related and HPV-unrelated, should be considered as two separate entities with different management options. The incidence of HPV-related VIN is increasing worldwide and is implicated in carcinogenesis. Our objective is to investigate the use of p16INK4a immunostaining or p16INK4a/p53 double staining for the detection of HPV-related disease to overcome the problem that histological criteria often have significant overlap.