Ricerc@Sapienza

Laryngopharyngeal reflux disease (LPRD) is defined as the retrograde flow of stomach content to the upper aero-digestive structures, with an estimate incidence about 4-10% of the general population.(1). LPRD is used to describe the pathological condition caused by the reflux of gastric and/or duodenal juices to the larynx, oropharynx and/or nasopharynx, through the upper oesophagus sphincter (UES). The most frequent symptoms are dysphonia, chronic cough, sore throat, excess throat mucus and pharyngeus globous. Endoscopy
evidence related to this pathology could be laryngeal oedema, laryngeal hyperaemiagranulomatosis and polypoid lesions of the larynx