Ricerc@Sapienza

Introduction: Chronic pharyngitis is one of the most frequent diseases of the upper
aerodigestive pathways. Gastro-esophageal reflux plays an important role in the g
this disease. In fact, the excessive exposure of the pharynx to the gastric contents leads to a
chronic irritation of the upper airways.
On the basis of the foregoing, the study of the present work aims to document the effect of
pastilles composed of xanthan gum, sodium hyaluronate, mannitol, sodium hydrogen
carbonate, sorbitol, citric acid, aspartame, vitamin C, aroma, zinc citrate dihydrate.
variation of salivary pH, of the symptomatology and of the objective picture in subjects
affected by secondary interest in acidity of the oral cavity.
Materials and methods: 50 subjects were recruited. They were enrolled by the affiliated
users to three ENT centers and supported by a gastroenterologist (Naples), 50 (25 males
and 25 females) with average age of 37aa, Min 6 aa, Max 65 aa patients affected by
secondary to acidity of the oral cavity. For each patient an objective examination was
performed and then the salivary pH changes were evaluated, using indicator maps, and
furthermore, the Reflux Symptoms Index (RSI) and Reflux Finding Scores (RFS) were
administered before, during and after therapy to monitor the subjectivity of the
symptomatology and the laryngeal objective picture.
Results: The survey performed allowed to establish a clear improvement in all phases of
the study, both as regards the effects on pH, both on the side of the symptomatology and on
the laryngeal objective.
Discussion: The motivation for improving the clinical condition of the subjects is due to the
therapeutic properties of the substances used. In particular: the hyaluronic acid has a
regenerating power of the mucosa; carbomer and Xanthana Gum have a viscoelastic
behavior and contribute to the potency of ac. High molecular weight hyaluronic acid
through the formation of a hydrocomplex of high tolerability mucoadhesive polymers.
Conclusions: Undoubtedly it is a product capable of restoring the physiological conditions
of the oral cavity and the very first airways and their use not only acts as a restoration of the
physiological conditions of the oral cavity, but also as a preventive action for the
appearance of local and systemic diseases.