Intronic Determinants Coordinate Charme lncRNA Nuclear Activity through the Interaction with MATR3 and PTBP1
01 Pubblicazione su rivista
Desideri F., Cipriano A., Petrezselyova S., Buonaiuto G., Santini T., Kasparek P., Prochazka J., Janson G., Paiardini A., Calicchio A., Colantoni A., Sedlacek R., Bozzoni I., Ballarino M.
ISSN: 2211-1247
Desideri et al. study the role of the chromatin-retained isoform of Charme, a lncRNA that regulates myogenesis. They find that a MATR3/PTBP1/pCharme assembly drives the retention and the function of the lncRNA. CRISPR-Cas9 deletion of pCharme intron-1 leads to the transcript delocalization and to heart defects in vivo.